ACRP Certified Professional : ACRP-CP

  • Exam Code: ACRP-CP
  • Exam Name: ACRP Certified Professional Exam
  • Updated: Aug 15, 2026
  • Q & A: 127 Questions and Answers

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- ICH Guidelines
  • 1. E11 Pediatric Trials
  • 2. E6(R2)/E6(R3) Good Clinical Practice
  • 3. E9 Statistical Principles
  • 4. E2A Expedited Reporting
  • 5. E8 General Considerations for Clinical Trials
Professionalism and Ethical Practice15%- Professional standards
  • 1. Role responsibilities and boundaries
  • 2. Confidentiality and conflict of interest
- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
Data Management and Informatics17%- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
Study Design and Conduct17%- Study implementation
  • 1. Study monitoring and oversight
  • 2. Investigational product management
  • 3. Site selection and activation
- Study planning
  • 1. Protocol development and amendments
  • 2. Sample size and statistical considerations
  • 3. Study population and eligibility criteria
Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Clinical care and management of research participants
  • 1. Continuity of medical care
  • 2. Standard of care vs protocol requirements
  • 3. Informed consent development and review
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
Clinical Study Operations15%- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
- Project management
  • 1. Timeline and budget management
  • 2. Vendor and stakeholder management

ACRP Certified Professional Sample Questions:

1. A sponsor writes a protocol comparing an IP XYZ to a marketed drug ABC to determine if XYZ is more efficacious in the target population than ABC. Both drugs are prepared in identically masked IV bags and distributed according to the randomization scheme outlined in the protocol such that the study team is unaware of the treatment assignment.
Which of the following is an appropriate title for this study?

A) A randomized, open-label, comparator study comparing the efficacy of XYZ to ABC in the target population
B) A randomized, double-blind, superiority study comparing the efficacy of XYZ to ABC in the target population
C) A randomized, single-blind, placebo-controlled study comparing the efficacy of XYZ to ABC in the target population
D) A randomized, double-blind, double-dummy, superiority study comparing the efficacy of XYZ to ABC in the target population


2. Centralized monitoring can:

A) Enable appropriate stratification of subject enrollment.
B) Confirm why sites are deviating from the protocol.
C) Identify IP accountability and storage issues.
D) Indicate the need to send monitors to perform onsite visits.


3. A Phase I drug trial has been completed and preparations are being made to proceed to a Phase II trial. Who is responsible for revising the IB with this updated information?

A) Investigator
B) Health authority
C) Sponsor
D) DSMB/IDMC


4. A study is using an EDC system. After the data is entered into EDC, who is the next to review and conduct SDV of this data?

A) QA Department
B) Sponsor
C) Monitor
D) Data Manager


5. The IRB/IEC has decided to not approve a clinical trial. Who must they notify in writing?

A) PI
B) Regulatory Agency
C) CRC
D) Sponsor


Solutions:

Question # 1
Answer: B
Question # 2
Answer: D
Question # 3
Answer: C
Question # 4
Answer: C
Question # 5
Answer: A

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